Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716.

نویسندگان

  • G Colombo
  • R Agabio
  • M Fà
  • L Guano
  • C Lobina
  • A Loche
  • R Reali
  • G L Gessa
چکیده

The present study assessed the efficacy of the cannabinoid CB1 receptor antagonist, SR-141716, in reducing voluntary ethanol intake in selectively bred Sardinian alcohol-preferring (sP) rats. Ethanol (10%, v/v) and food were available in daily 4 h scheduled access periods; water was present 24 h/day. The acute administration of a 2.5 and a 5 mg/kg dose of SR-141716 selectively reduced ethanol intake, whereas a 10 mg/kg dose of SR-141716 reduced to a similar extent both ethanol and food intake. These results suggest that the cannabinoid CB1 receptor is involved in the mediation of the ethanol-reinforcing effects in sP rats.

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عنوان ژورنال:
  • Alcohol and alcoholism

دوره 33 2  شماره 

صفحات  -

تاریخ انتشار 1998